Arsenal must beat Dinamo Zagreb at the Emirates to maintain their hopes of qualifying for the last 16 of the Champions League.
The Gunners have progressed from the group stage every year since 1999, but their destiny is out of their hands with two games remaining.
Should Olympiakos avoid defeat at Group F leaders Bayern Munich then both sides will qualify for the last 16 and Arsenal will be out.
However, if Bayern win and Arsenal triumph against Dinamo, then the Gunners could still progress ahead of the Greek side on the final matchday.
The good news for the hosts is that Dinamo have lost all three Champions League matches since winning the reverse fixture 2-1 in September and have not won any of their last 11 away games in the competition.
However, Arsene Wenger admitted his side are in a "difficult moment" after losing 2-1 to West Brom on Saturday.
The Gunners have won just one of their last five games in all competitions and saw Francis Coquelin and Mikel Arteta join a lengthy injury list at the weekend.