Real could all but end Atletico's title defence should they beat Sevilla and then overcome Diego Simeone's men in Saturday's Madrid derby, although they have failed to beat their city rivals in six tries already this season.
Two victories would put Real 10 points clear of their city rivals and seven clear of Barcelona for at least 24 hours, before the Catalans they travel to face Athletic Bilbao on Sunday.
However, having thrown away a lead in the title race last spring, Real manager Carlo Ancelotti insists the championship will go down to the wire.
"The game against Sevilla is risky if we don't give our best. The most important match is tomorrow, not the derby," said the Italian.
"We can increase the gap on our rivals, so we will play our strongest team.
"The league will be resolved at the end of the season, just like last season. It is important to have an advantage at the moment, but nothing is decided yet."
Ronaldo will complete his suspension on Wednesday whilst Fabio Coentrao, Pepe and Luka Modric miss out through injury.
Sevilla boss Unai Emery has built his side on attack.
Carlos Bacca is the club's leading scorer with 12 but there are plenty of other threats offered by Barcelona loanees Gerard Deulofeu and Denis Suarez.
